Comment: single receptors, dual second messengers.
نویسندگان
چکیده
منابع مشابه
Second Messengers.
Second messengers are small molecules and ions that relay signals received by cell-surface receptors to effector proteins. They include a wide variety of chemical species and have diverse properties that allow them to signal within membranes (e.g., hydrophobic molecules such as lipids and lipid derivatives), within the cytosol (e.g., polar molecules such as nucleotides and ions), or between the...
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The past four decades have witnessed extraordinary advances in the molecular understanding of neurotransmitters, their receptors, and second messengers. This essay highlights a selected group of particular notable discoveries, emphasizing seminal findings that have transformed thinking in the field.
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Neurohypophysial hormone receptors and second messengers were studied in trout (Oncorhynchus mykiss) hepatocytes. Arginine vasotocin (AVT) and isotocin (IT) elicited a concentration-dependent inhibition of cAMP accumulation in the presence of 5x10(-8) M glucagon (maximal effect for 4.5x10(-7) M and 1.4x10(-7) M, half-maximal effect for 2.1x10(-8) M and 0.7x10(-8) M, AVT and IT respectively). Th...
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1. Pressure-sensitive mechanosensory (P) neurones of the leech Hirudo medicinalis produce two responses to serotonin (5-HT): activation of a Cl- conductance and of a non-selective monovalent cation conductance. The effects of channel blockers, the receptor pharmacology and the second-messenger dependence of these responses were studied in voltage-clamped P cells in culture. Antagonists were app...
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Some lipids act as hormones to induce responses in target tissues whereas others influence the behavior of cell-surface receptors and/or serve as second messengers; i.e. they are formed as part of the cellular response to extracellular agonists, and directly affect protein kinases, ion channels and other systems that govern cell behavior. Our understanding of these functions on a structural lev...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1992
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend.6.4.1316545